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For the first time on PodcastRx, we're (finally) addressing some listener feedback! One of Chris's correctional provider contacts wanted to hear a show devoted to "all things heartburn and gastric reflux", and we were more than happy to oblige.
For the main discussion, Chris covers the differences among treatment classes for heartburn and reflux medications, the latest treatment guidelines, whether proton pump inhibitors deserve a bad reputation, concerns about antacid overuse, and non-pharmacologic considerations.
Before that, Chris shares a few updates related to
-New motion sickness drug approval
-Updated refractory constipation guidelines
-Upadacitinib vs. adalimumab trial for rheumatoid arthritis
-Treating scabies with ivermectin vs. permethrin
-Bismuth quadruple therapy for H. pylori
-GLP-1 suicide warnings
And though we missed Valentine's Day, we close out the show with a look at the fascinating pharmacy origins of a chalky, but clever Valentine's Day confection.
Sponsor Links:
Music in this Episode:
The Retro Synth by Art Haiz
Vitals & Headlines (Suno AI)
Breezy Thoughts (Suno AI)
Trivia Time Ticker (Suno AI)
Reference Links/Further Reading:
Into the Clinic:
FDA Greenlights First Motion Sickness Drug in More than 40 Years
Prevention and Treatment of Motion Sickness
AGA Clinical Practice Update on Evaluation and Management of Refractory Constipation: Expert Review
Not All Drugs Approved for Rheumatoid Arthritis Are Equal for Pain Relief
Cost-Effectiveness of First-Line Regimens for Helicobacter pylori Infection in the United States
Main Discussion:
Guidelines & Pharmacotherapy
- American College of Gastroenterology (2022). ACG Clinical Guideline: Diagnosis and Management of Gastroesophageal Reflux Disease. AJG Link
- Katz PO, et al. Guidelines for the diagnosis and management of GERD. Am J Gastroenterol. 2013.
- US Pharmacist. Standards of Care for GERD. US Pharmacist
PPI Safety & Long-Term Use
- Freedberg DE, Kim LS, Yang YX. The risks and benefits of long-term use of proton pump inhibitors. Gastroenterology. 2017.
- Scarpignato C, et al. Effective and safe proton pump inhibitor therapy in acid-related diseases. BMC Med. 2016.
- American Gastroenterological Association (AGA). Clinical Practice Update: Deprescribing PPIs. 2022.
Rebound Acid Hypersecretion
- Reimer C, et al. PPI therapy induces acid-related symptoms after withdrawal in healthy volunteers. Gastroenterology. 2009.
- AGA Clinical Practice Update (2022) – tapering strategies for discontinuing PPIs.
Antacid Use & Long-Term Concerns
- StatPearls. Antacids. NCBI Bookshelf
- Drugs.com. Antacids – Monograph & Precautions. Drugs.com
- International Foundation for Gastrointestinal Disorders (IFFGD). Antacids and Your Health. IFFGD
- Verywell Health. Antacid Side Effects. Verywell Health
Non-Pharmacologic Interventions
- US Pharmacist. Lifestyle Modifications for GERD. US Pharmacist
- NIDDK. GERD – Causes, Treatment, and Lifestyle Tips. NIDDK
Additional Resources
- UpToDate. Gastroesophageal reflux disease: Management overview. (subscription required)
- AGA Clinical Practice Updates – Lifestyle and pharmacologic management of GERD.
Trivia Capsule
The Pharmacist Who Launched America's Modern Candy Industry
